普罗布考联合阿托伐他汀治疗大动脉粥样硬化性脑梗死的临床研究

　　Abstract:

　　Objective

　　To investigate the effect of probucol combined with atorvastatin in treatment of large artery atherosclerotic cerebral infarction.

　　Methods

　　Patients (100 cases) with large artery atherosclerotic cerebral infarction in Xingtai Third Hospital from February 2013 to February 2015 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Atorvastatin Calcium Tablets before bedtime, 20 mg/time, once daily. Patients in the treatment group were po administered with Probucol Tablets on the basis of the control group, 500 mg/time, twice daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacies were evaluated, and antioxidant capacity, vascular endothelial function, IMT, and plaque area in two groups were compared.

　　Results

　　After treatment, the clinical efficacies in the control and treatment groups were 72.0% and 88.0%, respectively, and there was difference between two groups (P < 0.05). After treatment, ox-LDL and MDA in two groups were significantly decreased, but the SOD in two groups was significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the ET-1 in two groups were significantly decreased, but the NO and FMD in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, IMT and plaque area in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05).

　　Conclusion

　　Probucol combined with atorvastatin has clinical curative effect in treatment of large artery atherosclerotic cerebral infarction, and can improve stress response and vascular endothelial function, decrease IMT and plaque area, which has a certain clinical application value.